RESUMO
BACKGROUND: Clinical independent predictors of inducible sustained ventricular tachycardia (VT) during electrophysiologic study (EPS) are not known in patients with chronic Chagas' heart disease. The purpose of this investigation was to fill this gap. METHODS: The medical charts of 47 patients with a positive serology for Chagas' disease who had undergone EPS between September 2006 and July 2012 at our institution were reviewed. Reasons for the EPS were the presence of unexplained syncope, non-sustained ventricular tachycardia (NSVT) on either resting ECG or 24 h-Holter monitoring as well as a LVEF < 55% and > 35% at echocardiography. A stepwise logistic regression analysis was performed to identify noninvasive predictors of inducible sustained VT/ventricular fibrillation during EPS. RESULTS: On univariate analysis, syncopal episodes (p = 0.04), amiodarone therapy (p < 0.005), diastolic blood pressure (p = 0.03), creatinine serum levels (p < 0.001), potassium serum levels (p < 0.001), and lengthening of the QRS complex (p = 0.03) were associated with inducible sustained VT during EPS. In the multivariate model, amiodarone therapy (p = 0.03; hazard ratio = 10; Wald coefficient = 4.5; 95% confidence interval 1.2 to 85.2) was the only variable retained as independent predictor of inducible sustained VT during EPS. CONCLUSION: Amiodarone therapy was the only independent variable associated with sustained VT inducibility during EPS in patients with chronic Chagas' heart disease.
RESUMO
Objetivo: Este estudo dispõe-se a estudar algumas variáveis relacionadas ao consumo de substâncias psicoativas entre escolares do ensino médio do município de São José do Rio Preto, SP, Brasil. Método:Utilizou-se um estudo de corte transversal em escolas públicas do ensino médio do município com uma amostragem de conglomerados. Os questionários foram aplicados de maneira coletiva nas classes e mantidos sem identificação. No total, foram aplicados 1041 questionários. Resultados: Neste estudo encontrou-se uma associação entre o uso de cocaína e os seguintes fatores: relacionamento nocivo com os pais, com o sexo masculino, ser solteiro, não morar com pelo menos um dos pais e não ter e/ou não praticar uma religião. O uso de crack teve prevalência superior no sexo masculino. O uso de anfetamina apresentou prevalências inferiores em escolares que viviam com pelo menos um dos pais. O uso de alucinógeno associou-se a um relacionamento ruim com o pai e com o fato de não ter uma religião. Conclusão: No presente estudo, verificou-se que: o relacionamento com os pais, morar com pelo menos um dos pais e a religiosidade podem estar associados a um menor uso de algumas substâncias. Elaborar projetos para a prevenção e tratamento dos usuários que valorizem o aspecto religiosidade pode tornar os programas de prevenção mais eficazes, visto que a religiosidade vem se mostrando como um importante fator associado a um uso menor de drogas.
Objective: The present study aims at studying some variables related to drug abuse among high-school students in São José do Rio Preto, São Paulo, Brazil. Method: A cross-sectional survey was carried out in São José do Rio Preto. A self-applicable questionnaire was given to a proportional sample of 1041 teenagers enrolled in 9th, 10th, and 11th grades in public schools. Results: Significantly, a superior prevalence of cocaine consumption was associated with a stressfully relationship with both parents, with males, being single, notliving with his/her parent(s), and do not have and/or do not practice a religion. Crack use was more prevalent in males. Amphetamines consumption was less prevalent in those who live with, at least, one parent. The useof hallucinogens was associated with a stressful relationship with his/her father and to the fact of not having a religion. Conclusion: This study shows that the relationship with both parents, to live with one of them,and the religiosity could be associated with less prevalence of drug use. Prevention and treatment projects that explore religiosity would turn the prevention programs more efficient, once religiosity seems to be an important factor associated with lower drug use.
